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KMID : 1134120070100030173
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Journal of Breast Cancer
2007 Volume.10 No. 3 p.173 ~ p.180
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Cancer Stem Cells Downstream Regulated Gene 2 in Breast Cancer
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Hur Min-Hee
Gabriela Dontu
Max S. Wicha
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Abstract
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Recent results have supported the cancer stem cells hypo- thesis in which tumors originate from tissue stem cells or their early progenitors and, as a result, produce tumors that retain stem cell properties. These properties include self-renewal that drives tumorigenesis and differentiation that contributes to cellular heterogeneity. The number of these cells is very small, and is tightly controlled by the self-renew- al pathway and the signals of their environment (niche). Evidence for the existence of cancer stem cells has been reported for a number of human cancers including leukemia, cancers of the breast, brain, and colon. Although our under- standing of the biology of these cancer stem cells remains rudimentary, the existence of these cells has implications for current conceptualization of malignant transformation and targeted therapy for the treatment of cancer.
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KEYWORD
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Cancer stem cells, Self renewal, Targeted therapy
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